Histology Resource Core (HRC)


Formerly known as the Department of Surgery Histology Core  

Please contact us at histocore@surgery.wisc.edu to coordinate sample drop off and pick up. 

Overview of Services

The primary objective of the HRC is to provide a broad range of high-quality histology methods and resources to support basic, translational, and clinical science research at our institution and across the greater research community. 

Our vision is to offer affordable histological services to investigators that complement, support, and advance the innovative research missions of our clients.

The HRC is here to provide support for your project from start to finish. We are open to all UW investigators and external clients.

Our facility offers a broad range of high-quality histological and immunohistochemical services on a fee-for-service basis. Services include routine histology procedures, staining, custom protocol development, and training/education. We work with animal and human tissue up to BSL 2 and utilize paraffin and frozen techniques. Our routine histology procedures include tissue processing, embedding, frozen and paraffin sectioning, H&E staining, and imaging.

We currently offer over 15 different types of special stains, including trichrome, PAS, MSB, ORO, and more, and are always looking for opportunities to expand our catalog. 

IHC is available with brightfield or immunofluorescent detection. We have a catalog of over 70 verified antibodies at our disposal at no additional cost to the researcher. Our IHC protocols include multiplex labeling and same-species staining.

Our core provides the researcher with a unique opportunity to design and plan a study that optimizes the best tissue processing and staining techniques available. Individual attention to protocol and technique development allows us to offer personalized services for research and development. For researchers, this can look like developing a new antibody titration, collaborating on a dissection technique, creating a new multiplex staining protocol, or a specialized sectioning protocol.

We also offer training and education for microscopy and staining. We can work with you one-on-one or in a group as we go over microscopy basics, H&E staining, or IHC fundamentals.

Please click on the link listed below to see our current price list.


The Histology Resource Core (HRC) DOES NOT accept the following items: 

  • body fluids of any kind from any species
  • whole adult animals
  • samples containing prions, or any other biological agents at BSL 3 or higher

Samples that are submitted must either be frozen or placed in fixative

**Please contact the core if you have any questions about these items**


Acknowledging the Histo Core

It is your responsibility to cite the Histology Resource Core in the Acknowledgments section of your manuscript and notify the Core when manuscripts that used our services are submitted for publication, indicating the journal citation.

 “The author(s) thank the University of Wisconsin-Madison, Department of Surgery Histology Resource Core (HRC), Dr. Angela Gibson, MD, PhD, FACS, PI of the HRC, along with certified Histotechnologist Sierra Raglin, HTL (ASCP)CMP and Rebecca Lyons-Oelze, HTL (ASCP).”




Location and hours of operation

Hours Location

Monday - Friday

 9:00 AM - 5:00 PM

H4/337 CSC

600 Highland Ave

 Madison, WI 53792-7375

Links and Resources

  1. UW Department of Surgery Histology Core Website
  2. Department of Surgery and Urology Intranet
  3. Current Price List


Name Role Phone Email Location
Sierra Raglin
Core Manager
H4/337 CSC
Becky Lyons-Oelze
H4/337 CSC
Angela Gibson


Service list

Search available services: View: by category alphabetically
Histology (6)
Staining (17)
Project Set Up (4)
Imaging (1)
Labeling (2)
Equipment Usage Fees (2)